Which change occurs in pressure gradients as a result of IPC?

The most appropriate choice is that IPC, which stands for Intermittent Pneumatic Compression, leads to the normalization of fluid distribution. IPC works by applying external pressure to the limbs, which facilitates venous return and lymphatic drainage. This mechanism helps to create a favorable pressure gradient that encourages fluid to move away from the interstitial spaces and back into the circulation, thereby normalizing the distribution of fluids within the body. This is particularly beneficial for treating conditions like edema or venous insufficiency.

While alterations in vascular resistance and blood pH may occur in various physiological and pathological processes, they are not direct changes attributed to IPC's primary mechanism of creating beneficial pressure gradients in the tissues. Therefore, normalization of fluid distribution stands out as the most relevant and accurate description of the outcome associated with IPC.